At SMEx we are all for using cloud based SaaS products. We use Office 365 and Azure AD to manage our users, and we use Exclaimer Cloud - Signatures for Office 365 to manage our email signatures.
The way Exclaimer works is that it reads profile info from Azure AD and generates a signature during message transport and applies it to the message. It's actually quite a neat solution.
At SMEx, we have three offices and we include the address of the office in the signature. So instead of creating three different signatures in Exclaimer, we wanted one signature that can pull the address from the user's profile attributes.